Comprehensive regional and temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia‐induced gene expression patterns, and reveals a biphasic activation of genes in surviving tissue

@article{Rickhag2006ComprehensiveRA,
  title={Comprehensive regional and temporal gene expression profiling of the rat brain during the first 24 h after experimental stroke identifies dynamic ischemia‐induced gene expression patterns, and reveals a biphasic activation of genes in surviving tissue},
  author={Mattias Rickhag and T. Wieloch and G. Gid{\"o} and E. Elm{\'e}r and M. Krogh and J. Murray and S. Lohr and H. Bitter and Daniel J Chin and D. von Schack and M. Shamloo and K. Nikolich},
  journal={Journal of Neurochemistry},
  year={2006},
  volume={96}
}
  • Mattias Rickhag, T. Wieloch, +9 authors K. Nikolich
  • Published 2006
  • Biology, Medicine
  • Journal of Neurochemistry
  • In order to identify biological processes relevant for cell death and survival in the brain following stroke, the postischemic brain transcriptome was studied by a large‐scale cDNA array analysis of three peri‐infarct brain regions at eight time points during the first 24 h of reperfusion following middle cerebral artery occlusion in the rat. K‐means cluster analysis revealed two distinct biphasic gene expression patterns that contained 44 genes (including 18 immediate early genes), involved in… CONTINUE READING
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