Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features

@inproceedings{Ang2009ComprehensivePO,
  title={Comprehensive profiling of DNA methylation in colorectal cancer reveals subgroups with distinct clinicopathological and molecular features},
  author={Pei Woon Ang and Marie Loh and Natalia Liem and Pei Li Lim and Fabienne Grieu and Aparna Vaithilingam and Cameron F. E. Platell and Wei Peng Yong and Barry J Iacopetta and Richie Soong},
  booktitle={BMC Cancer},
  year={2009}
}
Most previous studies of the CpG island methylator phenotype (CIMP) in colorectal cancer (CRC) have been conducted on a relatively small numbers of CpG sites. In the present study we performed comprehensive DNA methylation profiling of CRC with the aim of characterizing CIMP subgroups. DNA methylation at 1,505 CpG sites in 807 cancer-related genes was evaluated using the Illumina GoldenGate® methylation array in 28 normal colonic mucosa and 91 consecutive CRC samples. Methylation data was… CONTINUE READING

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