Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.

Abstract

The cationic, ortho Mn(III) N-alkylpyridylporphyrins (alkyl=ethyl, E, and n-hexyl, nHex) MnTE-2-PyP(5+) (AEOL10113, FBC-007) and MnTnHex-2-PyP(5+) have proven efficacious in numerous in vivo animal models of diseases having oxidative stress in common. The remarkable therapeutic efficacy observed is due to their: (1) ability to catalytically remove O2… (More)
DOI: 10.1016/j.freeradbiomed.2013.01.006

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Cite this paper

@article{Weitner2013ComprehensivePS, title={Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+.}, author={Tin Weitner and Ivan Kos and Huaxin Sheng and Artak G Tovmasyan and J Thales S Rebouças and Ping Fan and D. Warner and Zeljko Vujaskovi{\'c} and Ines Batini{\'c}-Haberle and Ivan Spasojevi{\'c}}, journal={Free radical biology & medicine}, year={2013}, volume={58}, pages={73-80} }