Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors.

@article{Byrnes1993ComprehensiveME,
  title={Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors.},
  author={Vera W. Byrnes and Vinod Sardana and William A. Schleif and Jon Condra and Julie A Waterbury and Jill Wolfgang and Wende Long and Craig L. Schneider and A J Schlabach and Bohdan Wolanski},
  journal={Antimicrobial agents and chemotherapy},
  year={1993},
  volume={37 8},
  pages={1576-9}
}
The nonnucleoside reverse transcriptase (RT) inhibitors comprise a class of structurally diverse compounds that are functionally related and specific for the human immunodeficiency virus type 1 RT. Viral variants resistant to these compounds arise readily in cell culture and in treated, infected human. Therefore, the eventual clinical usefulness of the nonnucleoside inhibitors will rely on a thorough understanding of the genetic and biochemical bases for resistance. A study was performed to… CONTINUE READING