Comprehensive molecular profiling of lung adenocarcinoma

@inproceedings{Collisson2014ComprehensiveMP,
  title={Comprehensive molecular profiling of lung adenocarcinoma},
  author={Collisson and Joshua D. Campbell and Angela N. Brooks and Alice and Hilmar Berger and Juliann Chmielecki},
  booktitle={Nature},
  year={2014}
}
Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen (mean 8.9 mutations per megabase). Eighteen genes were statistically significantly mutated, including RIT1 activating mutations and newly described loss-of-function MGA mutations which are mutually… CONTINUE READING
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