Comprehensive molecular portrait using next generation sequencing of resected intestinal-type gastric cancer patients dichotomized according to prognosis.

@article{Bria2016ComprehensiveMP,
  title={Comprehensive molecular portrait using next generation sequencing of resected intestinal-type gastric cancer patients dichotomized according to prognosis.},
  author={Emilio Bria and Sara Pilotto and Michele Simbolo and Matteo Fassan and Giovanni d{\`e} Manzoni and Luisa Carbognin and Isabella Sperduti and Matteo A Brunelli and Ivana Cataldo and Anna Tomezzoli and Andrea Mafficini and G Turri and Niki Karachaliou and Rafael Rosell and Giampaolo Tortora and Aldo Scarpa},
  journal={Scientific reports},
  year={2016},
  volume={6},
  pages={22982}
}
In this study, we evaluated whether the presence of genetic alterations detected by next generation sequencing may define outcome in a prognostically-selected and histology-restricted population of resected gastric cancer (RGC). Intestinal type RGC samples from 34 patients, including 21 best and 13 worst prognostic performers, were studied. Mutations in 50 cancer-associated genes were evaluated. A significant difference between good and poor prognosis was found according to clinico-pathologic… CONTINUE READING