Comprehensive molecular biomarker identification in breast cancer brain metastases

@article{Schulten2017ComprehensiveMB,
  title={Comprehensive molecular biomarker identification in breast cancer brain metastases},
  author={Hans-Juergen Schulten and Mohammed Hasan Bangash and Sajjad Karim and Ashraf Dallol and Deema Hussein and Adnan A. Merdad and Fatma Khinaifis Al-thoubaity and Jaudah Al-Maghrabi and Awatif Jamal and Fahad Al-Ghamdi and Hani Choudhry and Saleh Baeesa and Adeel Ga Chaudhary and Mohammed Hussein Al-Qahtani},
  journal={Journal of Translational Medicine},
  year={2017},
  volume={15}
}
Breast cancer brain metastases (BCBM) develop in about 20–30% of breast cancer (BC) patients. BCBM are associated with dismal prognosis not at least due to lack of valuable molecular therapeutic targets. The aim of the study was to identify new molecular biomarkers and targets in BCBM by using complementary state-of-the-art techniques. We compared array expression profiles of three BCBM with 16 non-brain metastatic BC and 16 primary brain tumors (prBT) using a false discovery rate (FDR) p < 0… 

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