Comprehensive lung injury pathology induced by mTOR inhibitors

@article{Aparicio2009ComprehensiveLI,
  title={Comprehensive lung injury pathology induced by mTOR inhibitors},
  author={Guadalupe L. Aparicio and Mois{\'e}s Blanco Calvo and Vanessa Medina and Ovidio Fern{\'a}ndez and Paula Jim{\'e}nez and Martina Lema and Ang{\'e}lica Figueroa and Luis Miguel Ant{\'o}n Aparicio},
  journal={Clinical and Translational Oncology},
  year={2009},
  volume={11},
  pages={499-510}
}
Interstitial lung disease is a rare side effect of temsirolimus treatment in renal cancer patients. Pulmonary fibrosis is characterised by the accumulation of extracellular matrix collagen, fibroblast proliferation and migration, and loss of alveolar gas exchange units. Previous studies of pulmonary fibrosis have mainly focused on the fibro-proliferative process in the lungs. However, the molecular mechanism by which sirolimus promotes lung fibrosis remains elusive. Here, we propose an overall… 

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