Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes.

@article{Hillmer2011ComprehensiveLP,
  title={Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes.},
  author={Axel M Hillmer and Fei Yao and Koichiro Inaki and Wah Heng Lee and Pramila Nuwantha Ariyaratne and Audrey S. M. Teo and Xing Yi Woo and Zhenshui Zhang and Hao Zhao and Leena Ukil and Jieqi P. Chen and Feng Zhu and Jimmy B. Y. So and Manuel Salto-Tellez and Wan Ting Poh and Kelson Folkvard Braaten Zawack and Niranjan Nagarajan and Song Gao and Guoliang Li and Vikrant Kumar and Hui Ping J. Lim and Yee Yen Sia and Chee Seng Chan and See Ting Leong and Say Chuan Neo and Poh Sum D. Choi and Herv{\'e} Thoreau and Patrick O. B. Tan and Atif Shahab and Xiaoan Ruan and Jonas Van Den Bergh and Per Hall and Val{\`e}re Cacheux-Rataboul and Chia-Lin Wei and Khay Guan Yeoh and Wing-Kin Sung and Guillaume Bourque and Edison T. Liu and Yijun Ruan},
  journal={Genome research},
  year={2011},
  volume={21 5},
  pages={665-75}
}
Somatic genome rearrangements are thought to play important roles in cancer development. We optimized a long-span paired-end-tag (PET) sequencing approach using 10-Kb genomic DNA inserts to study human genome structural variations (SVs). The use of a 10-Kb insert size allows the identification of breakpoints within repetitive or homology-containing regions of a few kilobases in size and results in a higher physical coverage compared with small insert libraries with the same sequencing effort… CONTINUE READING
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