Comprehensive literature review and statistical considerations for GWAS meta-analysis

@inproceedings{Begum2012ComprehensiveLR,
  title={Comprehensive literature review and statistical considerations for GWAS meta-analysis},
  author={Ferdouse Begum and Debashis Ghosh and George C. Tseng and Eleanor Feingold},
  booktitle={Nucleic acids research},
  year={2012}
}
Over the last decade, genome-wide association studies (GWAS) have become the standard tool for gene discovery in human disease research. While debate continues about how to get the most out of these studies and on occasion about how much value these studies really provide, it is clear that many of the strongest results have come from large-scale mega-consortia and/or meta-analyses that combine data from up to dozens of studies and tens of thousands of subjects. While such analyses are becoming… CONTINUE READING

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