Comprehensive intestinal T helper cell profiling reveals specific accumulation of IFN-γ+IL-17+coproducing CD4+ T cells in active inflammatory bowel disease.

@article{Globig2014ComprehensiveIT,
  title={Comprehensive intestinal T helper cell profiling reveals specific accumulation of IFN-γ+IL-17+coproducing CD4+ T cells in active inflammatory bowel disease.},
  author={Anna-Maria Globig and Nadine Hennecke and Bianca Martin and Maximilian Seidl and Guenther Ruf and Peter Hasselblatt and Robert Thimme and Bertram Bengsch},
  journal={Inflammatory bowel diseases},
  year={2014},
  volume={20 12},
  pages={2321-9}
}
OBJECTIVE Skewed T helper (TH) cell responses and specific functions of TH1, TH2, TH17, and Treg cells have been implicated in the pathogenesis of inflammatory bowel disease (IBD) that led to the establishment of the pathogenic TH1/TH2 and TH17/Treg cell imbalance paradigms. However, the relevant TH cell population driving mucosal inflammation is still unknown. METHODS We performed a comprehensive TH cell profiling of circulating and intestinal lymphocytes isolated from patients with Crohn's… CONTINUE READING