Comprehensive identification of internal structure and alternative splicing events in circular RNAs

@inproceedings{Gao2016ComprehensiveIO,
  title={Comprehensive identification of internal structure and alternative splicing events in circular RNAs},
  author={Yuan Gao and Jiemin Wang and Yi Zheng and Jinyang Zhang and Shuai X. Chen and Fangqing Zhao},
  booktitle={Nature communications},
  year={2016}
}
Although previous studies demonstrated circular RNAs (circRNAs) does not exclusively comprise mRNA exons, no study has extensively explored their internal structure. By combining an algorithm with long-read sequencing data and experimental validation, we, for the first time, comprehensively investigate internal components of circRNAs in 10 human cell lines and 62 fruit fly samples, and reveal the prevalence of alternative splicing (AS) events within circRNAs. Significantly, a large proportion… CONTINUE READING
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References

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Showing 1-10 of 42 references

Exon-intron circular RNAs regulate transcription in the nucleus

Li, Y Z.
Nat. Struct. Mol. Biol • 2015

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