Comprehensive identification of glycated peptides and their glycation motifs in plasma and erythrocytes of control and diabetic subjects.

@article{Zhang2011ComprehensiveIO,
  title={Comprehensive identification of glycated peptides and their glycation motifs in plasma and erythrocytes of control and diabetic subjects.},
  author={Qibin Zhang and Matthew E. Monroe and Athena A. Schepmoes and Therese R.W. Clauss and Marina A. Gritsenko and Da Meng and Vladislav A. Petyuk and Richard D. Smith and Thomas O. Metz},
  journal={Journal of proteome research},
  year={2011},
  volume={10 7},
  pages={3076-88}
}
Nonenzymatic glycation of proteins sets the stage for formation of advanced glycation end-products and development of chronic complications of diabetes. In this report, we extended our previous methods on proteomics analysis of glycated proteins to comprehensively identify glycated proteins in control and diabetic human plasma and erythrocytes. Using immunodepletion, enrichment, and fractionation strategies, we identified 7749 unique glycated peptides, corresponding to 3742 unique glycated… CONTINUE READING

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