Comprehensive identification and analysis of human accelerated regulatory DNA.

Abstract

It has long been hypothesized that changes in gene regulation have played an important role in human evolution, but regulatory DNA has been much more difficult to study compared with protein-coding regions. Recent large-scale studies have created genome-scale catalogs of DNase I hypersensitive sites (DHSs), which demark potentially functional regulatory DNA… (More)
DOI: 10.1101/gr.192591.115

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