Comprehensive histologic assessment helps to differentiate multiple lung primary nonsmall cell carcinomas from metastases.

@article{Girard2009ComprehensiveHA,
  title={Comprehensive histologic assessment helps to differentiate multiple lung primary nonsmall cell carcinomas from metastases.},
  author={Nicolas Girard and Charuhas G Deshpande and Christopher D. Lau and David T. Finley and Valerie Rusch and William Pao and William D Travis},
  journal={The American journal of surgical pathology},
  year={2009},
  volume={33 12},
  pages={1752-64}
}
The pathologic classification of nonsmall cell lung cancer (NSCLC) is evolving. Lung adenocarcinoma is morphologically heterogeneous, with mixtures of acinar, papillary, bronchioloalveolar, and solid patterns in more than 80% of cases. In case of synchronous or metachronous multiple NSCLC, the distinction of intrapulmonary metastases from independent primary tumors is of great clinical importance as it influences staging and potentially the therapeutic strategy. Here we took advantage of a… CONTINUE READING