Comprehensive genomic profiling of anal squamous cell carcinoma reveals distinct genomically defined classes.

@article{Chung2016ComprehensiveGP,
  title={Comprehensive genomic profiling of anal squamous cell carcinoma reveals distinct genomically defined classes.},
  author={Jon H. Chung and Eric M Sanford and Adrienne M Johnson and Samuel J Klempner and Alexa B Schrock and Norma Alonzo Palma and Rachel L. Erlich and Garrett M. Frampton and Zachery Chalmers and J Vergilio and Douglas Adam Rubinson and James X. Sun and Juliann Chmielecki and Roman Yelensky and James H Suh and Doron M Lipson and Titto John George and Julia A Elvin and P J Stephens and V A Miller and Jeffrey S. Ross and Siraj M Ali},
  journal={Annals of oncology : official journal of the European Society for Medical Oncology},
  year={2016},
  volume={27 7},
  pages={1336-41}
}
BACKGROUND Squamous cell cancers of the anal canal (ASCC) are increasing in frequency and lack effective therapies for advanced disease. Although an association with human papillomavirus (HPV) has been established, little is known about the molecular characterization of ASCC. A comprehensive genomic analysis of ASCC was undertaken to identify novel genomic alterations (GAs) that will inform therapeutic choices for patients with advanced disease. PATIENTS AND METHODS Hybrid-capture-based next… CONTINUE READING

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