Comprehensive genomic profiles of small cell lung cancer

  title={Comprehensive genomic profiles of small cell lung cancer},
  author={Julie George and Jing Shan Lim and Se Jin Jang and Yupeng Cun and Luka Ozreti{\'c} and G K Kong and Frauke Leenders and Xin Lu and Lynnette Fern{\'a}ndez-Cuesta and Graziella Bosco and Christian M{\"u}ller and Ilona Dahmen and Nadine S. Jahchan and Kwon-Sik Park and Dian Yang and Anthony N Karnezis and Dedeepya Vaka and Angela Torres and Maia Segura Wang and Jan O. Korbel and Roopika Menon and S. M. Chun and Deokhoon Kim and Matt Wilkerson and Neil Hayes and David Engelmann and Brigitte M. P{\"u}tzer and M. K. Bos and Sebastian Y F Michels and Ignacija Vlasic and Danila Seidel and Berit Pinther and Philipp Schaub and Canton Becker and Janine Altmueller and Jun Yokota and Takashi Kohno and Reika Iwakawa and Koji Tsuta and Masayuki Noguchi and Thomas Muley and Hans Hoffmann and Philipp Albert Schnabel and Iver Petersen and Yuan Chen and Alex Soltermann and Verena Tischler and Chang Min Choi and Yong-Hee Kim and Pierre P. Massion and Yong Zou and Dragana M Jovanovi{\'c} and Milica Konti{\'c} and Gavin Wright and Prudence Anne Russell and Benjamin Solomon and Ina Koch and Michael Lindner and Lucia Anna Muscarella and Annamaria la Torre and John K. Field and Marko Jakopovi{\'c} and Jelena Kne{\vz}evi{\'c} and Esmeralda Casta{\~n}os-V{\'e}lez and Luca Roz and Ugo Pastorino and Odd-Terje Brustugun and Marius Lund-Iversen and Erik B Thunnissen and Jens Koehler and Martin Schuler and J. Botling and Martin Sandelin and Montserrat S{\'a}nchez-C{\'e}spedes and Helga Birgitte Salvesen and Viktor Achter and Ulrich Lang and Magdalena Bogus and Peter M Schneider and Thomas Zander and Sascha Ans{\'e}n and Michael J Hallek and J{\"u}rgen Wolf and Martin Vingron and Yasushi Yatabe and William D Travis and Peter N{\"u}rnberg and Christian Reinhardt and Sven Perner and Lukas Heukamp and Reinhard Buettner and Stefan A. Haas and Elisabeth M Brambilla and Martin Peifer and Julien Sage and Roman K. Thomas},
We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 and RB1, sometimes by complex genomic rearrangements. Two tumours with wild-type RB1 had evidence of chromothripsis leading to overexpression of cyclin D1 (encoded by the CCND1 gene), revealing an alternative mechanism of Rb1 deregulation. Thus, loss of the tumour suppressors TP53 and RB1 is obligatory in SCLC. We… CONTINUE READING
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