Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and separate evaluation of the different histological components

  title={Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and separate evaluation of the different histological components},
  author={Antje Ehrbrecht and U M{\"u}ller and Marietta Wolter and Alexander Hoischen and Arend Koch and Bernhard Radlwimmer and Bertrand Actor and Antoaneta Mincheva and Torsten Pietsch and Peter Lichter and Guido Reifenberger and Ruthild G. Weber},
  journal={The Journal of Pathology},
Desmoplastic medulloblastoma (DMB) is a malignant cerebellar tumour composed of two distinct tissue components, pale islands and desmoplastic areas. Previous studies revealed mutations in genes encoding members of the sonic hedgehog pathway, including PTCH, SMOH and SUFUH in DMBs. However, little is known about other genomic aberrations. We performed comparative genomic hybridization (CGH) analysis of 22 sporadic DMBs and identified chromosomal imbalances in 20 tumours (91%; mean, 4.9… 

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