Comprehensive genome analysis of 203 genomes provides structural genomics with new insights into protein family space

@article{Marsden2006ComprehensiveGA,
  title={Comprehensive genome analysis of 203 genomes provides structural genomics with new insights into protein family space},
  author={Russell L. Marsden and David Lee and Michael Maibaum and Corin Yeats and Christine A. Orengo},
  journal={Nucleic Acids Research},
  year={2006},
  volume={34},
  pages={1066 - 1080}
}
We present an analysis of 203 completed genomes in the Gene3D resource (including 17 eukaryotes), which demonstrates that the number of protein families is continually expanding over time and that singleton-sequences appear to be an intrinsic part of the genomes. A significant proportion of the proteomes can be assigned to fewer than 6000 well-characterized domain families with the remaining domain-like regions belonging to a much larger number of small uncharacterized families that are largely… CONTINUE READING

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