Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes

@inproceedings{Lange2010ComprehensiveGA,
  title={Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes},
  author={Nancy E. Lange and Xiaobo Zhou and Jessica A. Lasky-Su and Blanca E. Himes and Ross Lazarus and Manuel E. Soto-Quiros and Lydiana Avila and Juan C Celed{\'o}n and Catherine M Hawrylowicz and Benjamin A. Raby and Augusto A Litonjua},
  booktitle={BMC Medical Genetics},
  year={2010}
}
Prior studies suggest a role for a variant (rs5743836) in the promoter of toll-like receptor 9 (TLR9) in asthma and other inflammatory diseases. We performed detailed genetic association studies of the functional variant rs5743836 with asthma susceptibility and asthma-related phenotypes in three independent cohorts. rs5743836 was genotyped in two family-based cohorts of children with asthma and a case-control study of adult asthmatics. Association analyses were performed using chi square… CONTINUE READING

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