Comprehensive gene- and pathway-based analysis of depressive symptoms in older adults.

@article{Nho2015ComprehensiveGA,
  title={Comprehensive gene- and pathway-based analysis of depressive symptoms in older adults.},
  author={K. Nho and V. Ramanan and E. Horgusluoglu and S. Kim and M. Inlow and S. Risacher and B. McDonald and M. Farlow and T. Foroud and S. Gao and C. Callahan and H. Hendrie and A. Niculescu and A. Saykin},
  journal={Journal of Alzheimer's disease : JAD},
  year={2015},
  volume={45 4},
  pages={
          1197-206
        }
}
Depressive symptoms are common in older adults and are particularly prevalent in those with or at elevated risk for dementia. Although the heritability of depression is estimated to be substantial, single nucleotide polymorphism-based genome-wide association studies of depressive symptoms have had limited success. In this study, we performed genome-wide gene- and pathway-based analyses of depressive symptom burden. Study participants included non-Hispanic Caucasian subjects (n = 6,884) from… Expand
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