Comprehensive functional characterization of cancer–testis antigens defines obligate participation in multiple hallmarks of cancer

@article{Maxfield2015ComprehensiveFC,
  title={Comprehensive functional characterization of cancer–testis antigens defines obligate participation in multiple hallmarks of cancer},
  author={Kimberly E. Maxfield and Patrick J. Taus and Kathleen Corcoran and Joshua S. Wooten and Jennifer Macion and Yunyun Zhou and Mark D. Borromeo and Rahul K. Kollipara and Jingsheng Yan and Yang Xie and Xian-Jin Xie and Angelique W Whitehurst},
  journal={Nature Communications},
  year={2015},
  volume={6}
}
Tumours frequently activate genes whose expression is otherwise biased to the testis, collectively known as cancer–testis antigens (CTAs). The extent to which CTA expression represents epiphenomena or confers tumorigenic traits is unknown. In this study, to address this, we implemented a multidimensional functional genomics approach that incorporates 7 different phenotypic assays in 11 distinct disease settings. We identify 26 CTAs that are essential for tumor cell viability and/or are… 
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