Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus.

@article{Sigurdsson2008ComprehensiveEO,
  title={Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus.},
  author={Snaevar Sigurdsson and Harald H. H. G{\"o}ring and Gudlaug T Kristjansdottir and Lili Milani and Gunnel Nordmark and Johanna K. Sandling and M L Eloranta and Di Feng and Niquiche Sangster-Guity and Iva Gunnarsson and Elisabet Svenungsson and Gunnar K Sturfelt and Andreas J{\"o}nsen and Lennart Truedsson and Betsy Jo Barnes and Gunnar Alm and Lars R{\"o}nnblom and Ann-Christine Syv{\"a}nen},
  journal={Human molecular genetics},
  year={2008},
  volume={17 6},
  pages={872-81}
}
We analyzed a comprehensive set of single-nucleotide polymorphisms (SNPs) and length polymorphisms in the interferon regulatory factor 5 (IRF5) gene for their association with the autoimmune disease systemic lupus erythematosus (SLE) in 485 Swedish patients and 563 controls. We found 16 SNPs and two length polymorphisms that display association with SLE (P… CONTINUE READING