Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer.

@article{Kondelin2018ComprehensiveEO,
  title={Comprehensive evaluation of coding region point mutations in microsatellite-unstable colorectal cancer.},
  author={Johanna Kondelin and Kari Salokas and Lilli Saarinen and Kristian Ovaska and Heli Rauanheimo and Roosa-Maria Plaketti and Jiri Hamberg and Xiaonan Liu and Leena Yadav and Alexandra E. Gylfe and Tatiana Cajuso and Ulrika A H{\"a}nninen and Kimmo Palin and Heikki Ristolainen and Riku Katainen and Eevi Kaasinen and Tomas Tanskanen and Mervi M Aavikko and Minna Taipale and Jussi Taipale and Laura Renkonen-Sinisalo and Anna H Lepist{\"o} and Selja Koskensalo and Jan B{\"o}hm and Jukka-Pekka Mecklin and Halit Ongen and Emmanouil T. Dermitzakis and Outi Kilpivaara and Pia Vahteristo and Mikko M. Turunen and Sampsa Hautaniemi and Sari Tuupanen and Auli Karhu and Niko V{\"a}lim{\"a}ki and Markku Varjosalo and Esa Pitk{\"a}nen and Lauri A. Aaltonen},
  journal={EMBO molecular medicine},
  year={2018},
  volume={10 9}
}
Microsatellite instability (MSI) leads to accumulation of an excessive number of mutations in the genome, mostly small insertions and deletions. MSI colorectal cancers (CRCs), however, also contain more point mutations than microsatellite-stable (MSS) tumors, yet they have not been as comprehensively studied. To identify candidate driver genes affected by point mutations in MSI CRC, we ranked genes based on mutation significance while correcting for replication timing and gene expression… CONTINUE READING