Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.

@article{Addo2003ComprehensiveEA,
  title={Comprehensive epitope analysis of human immunodeficiency virus type 1 (HIV-1)-specific T-cell responses directed against the entire expressed HIV-1 genome demonstrate broadly directed responses, but no correlation to viral load.},
  author={Marylyn Martina Addo and Xu G. Yu and Almas Rathod and Daniel Cohen and Robert L. Eldridge and Daryld Strick and Mary N. Johnston and Colleen P Corcoran and Alysse G Wurcel and Cecily A Fitzpatrick and Margaret E Feeney and William R. Rodriguez and Nesli Basgoz and Rika Draenert and David R. Stone and Christian Brander and Philip J. R. Goulder and E. S. Rosenberg and Marcus Altfeld and Bruce D. Walker},
  journal={Journal of virology},
  year={2003},
  volume={77 3},
  pages={2081-92}
}
Cellular immune responses play a critical role in the control of human immunodeficiency virus type 1 (HIV-1); however, the breadth of these responses at the single-epitope level has not been comprehensively assessed. We therefore screened peripheral blood mononuclear cells (PBMC) from 57 individuals at different stages of HIV-1 infection for virus-specific T-cell responses using a matrix of 504 overlapping peptides spanning all expressed HIV-1 proteins in a gamma interferon-enzyme-linked… CONTINUE READING
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