Comprehensive comparison of the cytotoxic activities of onconase and bovine seminal ribonuclease.

@article{Matousek2003ComprehensiveCO,
  title={Comprehensive comparison of the cytotoxic activities of onconase and bovine seminal ribonuclease.},
  author={Jaroslav Matousek and Josef Sou{\vc}ek and Tom{\'a}s Slav{\'i}k and Milan Tom{\'a}nek and John R. E. Lee and Ronald T. Raines},
  journal={Comparative biochemistry and physiology. Toxicology & pharmacology : CBP},
  year={2003},
  volume={136 4},
  pages={343-56}
}
Onconase (ONC) and bovine seminal ribonuclease (BS-RNase) are homologs of bovine pancreatic ribonuclease (RNase A). Unlike RNase A, ONC and BS-RNase can evade the cytosolic ribonuclease inhibitor protein and are potent cytotoxins. Here, the endogenous cytotoxic activities of ONC and BS-RNase are compared in a wide variety of assays. Injections of ONC into… CONTINUE READING