Comprehensive and differential long-term characterization of the alpha-galactosidase A deficient mouse model of Fabry disease focusing on the sensory system and pain development

@inproceedings{eyler2016ComprehensiveAD,
  title={Comprehensive and differential long-term characterization of the alpha-galactosidase A deficient mouse model of Fabry disease focusing on the sensory system and pain development},
  author={Nurcan {\"U}çeyler and Lydia Biko and Dorothea Hose and Lukas Hofmann and Claudia L Sommer},
  booktitle={Molecular pain},
  year={2016}
}
BACKGROUND Fabry disease is an X-linked lysosomal storage disorder due to impaired activity of alpha-galactosidase A with intracellular accumulation of globotriaosylceramide. Associated small fiber pathology leads to characteristic pain in Fabry disease. We systematically assessed sensory system, physical activity, metabolic parameters, and morphology of male and female mice with alpha-galactosidase A deficiency (Fabry ko) from 2 to 27 months of age and compared results with those of age- and… CONTINUE READING