Comprehensive analysis of west nile virus-specific T cell responses in humans.

  title={Comprehensive analysis of west nile virus-specific T cell responses in humans.},
  author={Marion Christine Lanteri and John W. Heitman and Rachel E Owen and Thomas Busch and Nelly Gefter and Nancy E Kiely and Hany T Kamel and Leslie H. H. Tobler and Michael P. Busch and Phillip J Norris},
  journal={The Journal of infectious diseases},
  volume={197 9},
BACKGROUND Cellular responses have been shown to play a role in immune control and clearance of West Nile virus (WNV) in murine models. However, little is known about the immunogenic regions of the virus or the phenotype of responding T cells in human infection. METHODS Frozen peripheral blood mononuclear cells (PBMCs) from 35 WNV-infected blood donors were screened for virus-specific T cell responses by an interferon-gamma (IFN-gamma) enzyme-linked immunosorbent spot assay that used 452… CONTINUE READING
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