Comprehensive analysis of the secreted proteins of the parasite Haemonchus contortus reveals extensive sequence variation and differential immune recognition.

@article{Yatsuda2003ComprehensiveAO,
  title={Comprehensive analysis of the secreted proteins of the parasite Haemonchus contortus reveals extensive sequence variation and differential immune recognition.},
  author={Ana Patr{\'i}cia Yatsuda and Jeroen Krijgsveld and A. W. Cornelissen and Albert J. R. Heck and Erik de Vries},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 19},
  pages={16941-51}
}
Haemonchus contortus is a nematode that infects small ruminants. It releases a variety of molecules, designated excretory/secretory products (ESP), into the host. Although the composition of ESP is largely unknown, it is a source of potential vaccine components because ESP are able to induce up to 90% protection in sheep. We used proteomic tools to analyze ESP proteins and determined the recognition of these individual proteins by hyperimmune sera. Following two-dimensional electrophoresis of… CONTINUE READING
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