Comprehensive analysis of the role of von Willebrand factor and platelet glycoprotein VI- and α2β1-mediated collagen binding in thrombus formation

Abstract

Rare missense mutations in the von Willebrand factor (VWF) A3 domain that disrupt collagen binding, have been found in patients with a mild bleeding phenotype. However, the analysis of these aberrant VWF-collagen interactions has been limited. Here, we have developed mouse models of collagen binding mutants and analyzed the function of the A3 domain using… (More)

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Cite this paper

@inproceedings{Shida2014ComprehensiveAO, title={Comprehensive analysis of the role of von Willebrand factor and platelet glycoprotein VI- and α2β1-mediated collagen binding in thrombus formation}, author={Yasuaki Shida and Natalia Rydz and David Stegner and Christine Brown and Jeffrey D. Mewburn and Kate Sponagle and Ozge Danisment and Bredon Crawford and B{\'a}rbara Vidal and Carol A. Hegadorn and Cynthia M. Pruss and Bernhard Nieswandt and David P. Lillicrap}, year={2014} }