Comprehensive analysis of the role of DNA repair gene polymorphisms on risk of glioma.

  title={Comprehensive analysis of the role of DNA repair gene polymorphisms on risk of glioma.},
  author={Lara L Bethke and Emily C Webb and Anne Murray and Minouk J. Schoemaker and Christoffer Johansen and Helle Collatz Christensen and Kenneth Ross Muir and P. A. Mckinney and Sarah J. Hepworth and Polyxeni Dimitropoulou and Artitaya Lophatananon and Maria Feychting and Stefan L{\"o}nn and Anders Ahlbom and Beatrice Susanne Malmer and Roger Henriksson and Anssi Auvinen and Anne Kiuru and Tiina T Salminen and Anthony J Swerdlow and Richard S. Houlston},
  journal={Human molecular genetics},
  volume={17 6},
Much of the variation in inherited risk of glioma is likely to be explained by combinations of common low risk variants. The established relationship between glioma risk and exposure to ionizing radiation led us to examine whether variants in the DNA repair genes contribute to disease susceptibility. We evaluated 1127 haplotype-tagging single-nucleotide polymorphisms (SNPs) supplemented with 388 putative functional SNPs to capture most of the common variation in 136 DNA repair genes, in five… CONTINUE READING
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