Comprehensive analysis of the KSHV MiRNA targetome by Ago-HITS-CLIP

  title={Comprehensive analysis of the KSHV MiRNA targetome by Ago-HITS-CLIP},
  author={Irina Haecker and Lauren Appleby Gay and Alison M. Morse and Marty McCrory and Yajie Yang and Jianhong Hu and Lauren M. McIntyre and Rolf Renne},
  booktitle={Infectious Agents and Cancer},
The gamma-herpesvirus Kaposi’s Sarcoma-associated Herpesvirus (KSHV) is the etiological agent of Kaposi’s Sarcoma (KS), Primary Effusion Lymphoma (PEL) and a subset of Multicentric Castleman’s Disease (MCD) in immunocompromised individuals. As all herpesviruses KSHV has a latent and a lytic life cycle. Malignant cells in KS, PEL, and MCD are latently infected with KSHV. Interestingly, the virus encodes 12 miRNA genes giving rise to 25 mature miRNAs that are predominantly expressed during… CONTINUE READING