Comprehensive analysis of sphingosine-1-phosphate receptor mutants during zebrafish embryogenesis.

@article{Hisano2015ComprehensiveAO,
  title={Comprehensive analysis of sphingosine-1-phosphate receptor mutants during zebrafish embryogenesis.},
  author={Yu Hisano and Asuka Inoue and Kiyohito Taimatsu and Satoshi Ota and Rie Ohga and Hirohito Kotani and Michiko Muraki and Junken Aoki and Atsuo Kawahara},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2015},
  volume={20 8},
  pages={647-58}
}
The lipid mediator sphingosine-1-phosphate (S1P) regulates various physiological and pathological phenomena such as angiogenesis and oncogenesis. Secreted S1P associates with the G-protein-coupled S1P receptors (S1PRs), leading to the activation of downstream signaling molecules. In mammals, five S1prs have been identified and the genetic disruption of a single S1pr1 gene causes vascular defects. In zebrafish, seven s1prs have been isolated. We found that individual s1prs showed unique… CONTINUE READING