Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.

@article{Fujita1999ComprehensiveAO,
  title={Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes.},
  author={Takayoshi Fujita and Masaharu Kiyama and Yoshio Tomizawa and Takashi Kohno and Jun Yokota},
  journal={International journal of oncology},
  year={1999},
  volume={15 5},
  pages={927-34}
}
To date, the characteristics of p53 gene mutations in lung cancer have been extensively investigated. However, current estimates of p53 alterations are inaccurate, since most investigators have limited their analyses to exons 5 to 8 of the p53 gene. We examined 52 lung carcinoma cell lines and 106 primary non-small cell lung carcinomas (NSCLC) for mutations in the entire coding region of the p53 gene, from exons 2 to 11. High resolution single strand conformation polymorphism analysis was… CONTINUE READING

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