Comprehensive analysis of microRNA expression profile in malignant glioma tissues.

  title={Comprehensive analysis of microRNA expression profile in malignant glioma tissues.},
  author={Monika Piwecka and Katarzyna Rolle and Agnieszka Belter and Anna Maria Barciszewska and Marek Żywicki and Marcin Michalak and Stanisław Nowak and Mirosława Z. Naskręt-Barciszewska and Jan Barciszewski},
  journal={Molecular oncology},
  volume={9 7},
Malignant gliomas represent the most devastating group of brain tumors in adults, among which glioblastoma multiforme (GBM) exhibits the highest malignancy rate. Despite combined modality treatment, GBM recurs and is invariably fatal. A further insight into the molecular background of gliomagenesis is required to improve patient outcomes. The primary aim of this study was to gain broad information on the miRNA expression pattern in malignant gliomas, mainly GBM. We investigated the global miRNA… CONTINUE READING
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