Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides.

@article{Kaufmann2004ComprehensiveAO,
  title={Comprehensive analysis of human immunodeficiency virus type 1-specific CD4 responses reveals marked immunodominance of gag and nef and the presence of broadly recognized peptides.},
  author={Daniel E Kaufmann and Paul M. Bailey and John Sidney and Bradford S. Wagner and Phillip J Norris and Mary N. Johnston and Lisa A. Cosimi and Marylyn Martina Addo and Mathias Lichterfeld and Marcus Altfeld and Nicole Frahm and Christian Brander and Alessandro Sette and Bruce D. Walker and E. S. Rosenberg},
  journal={Journal of virology},
  year={2004},
  volume={78 9},
  pages={
          4463-77
        }
}
Increasing evidence suggests that human immunodeficiency virus type 1 (HIV-1)-specific CD4 T-cell responses contribute to effective immune control of HIV-1 infection. However, the breadths and specificities of these responses have not been defined. We screened fresh CD8-depleted peripheral blood mononuclear cells (PBMC) from 36 subjects at different stages of HIV-1 infection for virus-specific CD4 responses by gamma interferon enzyme-linked immunospot assay, using 410 overlapping peptides… CONTINUE READING
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