Comprehensive analysis of human endogenous retrovirus transcriptional activity in human tissues with a retrovirus-specific microarray.

@article{Seifarth2005ComprehensiveAO,
  title={Comprehensive analysis of human endogenous retrovirus transcriptional activity in human tissues with a retrovirus-specific microarray.},
  author={Wolfgang Seifarth and Oliver R Frank and Udo Zeilfelder and Birgit Spiess and Alex Greenwood and R{\"u}diger Hehlmann and Christine Leib-Moesch},
  journal={Journal of virology},
  year={2005},
  volume={79 1},
  pages={341-52}
}
Retrovirus-like sequences account for 8 to 9% of the human genome. Among these sequences, about 8,000 pol-containing proviral elements have been identified to date. As part of our ongoing search for active and possibly disease-relevant human endogenous retroviruses (HERVs), we have recently developed an oligonucleotide-based microarray. The assay allows for both the detection and the identification of most known retroviral reverse transcriptase (RT)-related nucleic acids in biological samples… CONTINUE READING
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