Comprehensive analysis of hormone and genetic variation in 36 genes related to steroid hormone metabolism in pre- and postmenopausal women from the breast and prostate cancer cohort consortium (BPC3).

@article{Beckmann2011ComprehensiveAO,
  title={Comprehensive analysis of hormone and genetic variation in 36 genes related to steroid hormone metabolism in pre- and postmenopausal women from the breast and prostate cancer cohort consortium (BPC3).},
  author={L. Beckmann and Anika Huesing and Veronica Wendy Setiawan and Pilar Amiano and Francoise Clavel-Chapelon and Stephen J. Chanock and David G. Cox and Ryan W. Diver and Laure Dossus and Heather Spencer Feigelson and Christopher A. Haiman and G{\"o}ran Hallmans and Richard B Hayes and Brian E. Henderson and Robert Nathaniel Hoover and David J. Hunter and Kay-Tee Khaw and Laurence N. Kolonel and Peter Kraft and Eiliv Lund and Lo{\"i}c Le Marchand and Petra H. M. Peeters and Elio Riboli and Dan O Stram and Gilles Thomas and Michael J. Thun and Rosario Tumino and Dimitirios Trichopoulos and Ulrich H Vogel and Walter C Willett and Meredith Yeager and Renatus Ziegler and Susan E. Hankinson and Rudolph R Kaaks},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2011},
  volume={96 2},
  pages={E360-7}
}
CONTEXT Sex steroids play a central role in breast cancer development. OBJECTIVE This study aimed to relate polymorphic variants in 36 candidate genes in the sex steroid pathway to serum concentrations of sex steroid hormones and SHBG. DESIGN Data on 700 genetic polymorphisms were combined with existing hormone assays and data on breast cancer incidence, within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nurses' Health Study (NHS) cohorts; significant… CONTINUE READING