Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians.

@article{Lanktree2010ComprehensiveAO,
  title={Comprehensive analysis of genomic variation in the LPA locus and its relationship to plasma lipoprotein(a) in South Asians, Chinese, and European Caucasians.},
  author={Matthew B. Lanktree and Sonia Savitri Anand and Salim Yusuf and Robert A Hegele},
  journal={Circulation. Cardiovascular genetics},
  year={2010},
  volume={3 1},
  pages={39-46}
}
BACKGROUND Functional copy number variation in the apolipoprotein(a) gene (LPA) underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein(a) [Lp(a)] particle. Genomic analysis of LPA, including both single-nucleotide polymorphisms (SNPs) and kringle IV type 2 (KIV-2) copy number, has yet to be performed. METHODS AND RESULTS First, we genotyped 49 SNPs within 100 kb of LPA in a multiethnic sample comprising South Asians (n=330), Chinese (n=304), and European… CONTINUE READING
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