Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients

@article{Kihara2014ComprehensiveAO,
  title={Comprehensive analysis of genetic alterations and their prognostic impacts in adult acute myeloid leukemia patients},
  author={Rika Kihara and Yasunobu Nagata and Hitoshi Kiyoi and T Kato and Eisuke Yamamoto and Kazuo Suzuki and Franklin Chen and Norio Asou and Shigeki Ohtake and Syuichi Miyawaki and Yoshihide Miyazaki and Toru Sakura and Yukihiro Ozawa and Noriko Usui and Heiwa Kanamori and Toru Kiguchi and Kohzoh Imai and Naokuni Uike and Fumihiko Kimura and Koichi Kitamura and Chiaki Nakaseko and Makoto Onizuka and Akihiro Takeshita and Fumihiro Ishida and Hitoshi Suzushima and Y Kato and Hiroshi Miwa and Yasuyuki Shiraishi and Kenichi Chiba and Hideyuki Tanaka and Satoru Miyano and Shuichiro Ogawa and Tomoki Naoe},
  journal={Leukemia},
  year={2014},
  volume={28},
  pages={1586-1595}
}
To clarify the cooperative roles of recurrently identified mutations and to establish a more precise risk classification system in acute myeloid leukemia (AML), we comprehensively analyzed mutations in 51 genes, as well as cytogenetics and 11 chimeric transcripts, in 197 adult patients with de novo AML who were registered in the Japan Adult Leukemia Study Group AML201 study. We identified a total of 505 mutations in 44 genes, while only five genes, FLT3, NPM1, CEBPA, DNMT3A and KIT, were… CONTINUE READING

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