Comprehensive analysis of UGT1A1 polymorphisms through high-resolution melting analysis and DNA sequencing.

Abstract

BACKGROUND Uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) is a key conjugating enzyme of bilirubin and the anti-tumor medication irinotecan. Comprehensive analysis of UGT1A1 gene polymorphisms may provide benefit by predicting pharmacokinetics and outcomes of treatment with irinotecan and certain antiviral medications. METHODS A high-resolution… (More)

Topics

Cite this paper

@article{Tsai2014ComprehensiveAO, title={Comprehensive analysis of UGT1A1 polymorphisms through high-resolution melting analysis and DNA sequencing.}, author={Shin-Yi Tsai and Tze-Kiong Er and Chin-Wen Lin and Jan-Gowth Chang}, journal={Clinical laboratory}, year={2014}, volume={60 6}, pages={1015-26} }