Comprehensive analysis of HLA-G: implications for recurrent spontaneous abortion.

  title={Comprehensive analysis of HLA-G: implications for recurrent spontaneous abortion.},
  author={Dara S. Berger and W. Allen Hogge and M. Michael Barmada and Robert E. Ferrell},
  journal={Reproductive sciences},
  volume={17 4},
Miscarriage is one of the most common pregnancy complications. Recurrent spontaneous abortion is defined as 2 or more pregnancy losses and may be associated with genetic variation. Human leukocyte antigen-G (HLA-G) is a ligand for natural killer (NK) cell receptors and has the ability to block NK cell activity, which if not blocked can potentially harm a fetus. Consequently a deletion or mutation of the HLA-G gene could lead to miscarriage. Our cases (n = 238) include Caucasian women… CONTINUE READING


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