Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities.

@article{Lauer2002ComprehensiveAO,
  title={Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities.},
  author={Georg M Lauer and Kei Ouchi and Raymond Tsang Chi Chung and Tam T. T. N. Nguyen and Cheryl L. Day and Deborah R Purkis and Markus Reiser and Arthur Y. Kim and Michaela Lucas and Paul Klenerman and Bruce D. Walker},
  journal={Journal of virology},
  year={2002},
  volume={76 12},
  pages={6104-13}
}
The hepatitis C virus (HCV)-specific CD8(+)-T-cell response is thought to play a critical role in HCV infection. Studies of these responses have largely relied on the analysis of a small number of previously described or predicted HCV epitopes, mostly restricted by HLA A2. In order to determine the actual breadth and magnitude of CD8(+)-T-cell responses in the context of diverse HLA class I alleles, we performed a comprehensive analysis of responses to all expressed HCV proteins. By using a… CONTINUE READING