Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C.

@article{Cox2005ComprehensiveAO,
  title={Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C.},
  author={Andrea L. Cox and Timothy L Mosbruger and Georg M Lauer and Drew Pardoll and David L Thomas and Stuart C. Ray},
  journal={Hepatology},
  year={2005},
  volume={42 1},
  pages={104-12}
}
We comprehensively studied the cellular immune response during acute human hepatitis C virus (HCV) infection by monthly prospective sampling of persons at high risk of infection. In 19 of 23 subjects, interferon-gamma-secreting T cells specific for 1 or more peptides spanning the entire HCV polyprotein were detected 1 to 3 months after infection. The median time to development of interferon gamma responses to HCV peptides was 33 days (range, 29-50 days), and these responses peaked between 180… CONTINUE READING
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