Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.

  title={Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.},
  author={W. Marston Linehan and Paul T. Spellman and Christopher J. Ricketts and Chad J Creighton and Suzanne S. Fei and Caleb A Davis and David A. Wheeler and Bradley A. Murray and Laura Schmidt and Cathy D. Vocke and Myron Peto and Abu Amar Mohamed Al Mamun and Eve Shinbrot and Anurag Sethi and Samira Brooks and W. Kimryn Rathmell and Angela N. Brooks and Katherine A Hoadley and A. Gordon Robertson and Denise Brooks and Reanne Bowlby and Sara N Sadeghi and Hui Shen and Daniel J Weisenberger and Moiz S. Bootwalla and Stephen B. Baylin and Peter W. Laird and Andrew D Cherniack and Gordon Saksena and Scott Mattox Haake and Jun Li and Han Liang and Yiling Lu and Gordon B. Mills and Rehan Akbani and Mark D. M. Leiserson and Benjamin J. Raphael and Pavana Anur and Donald P Bottaro and Laurence K Albiges and Nandita Barnabas and Toni K Choueiri and Bogdan Czerniak and Andrew K. Godwin and Abraham Ari Hakimi and Thai H. Ho and James Hsieh and Michael Ittmann and William Y. Kim and Bhavani Krishnan and Mar{\'i}a Jos{\'e} Beato Merino and Kenna R. Mills Shaw and Victor E. Reuter and Ed Reznik and Carl Simon Shelley and Brian Shuch and Sabina Signoretti and Ramaprasad Srinivasan and Pheroze Tamboli and George Thomas and Satish K. Tickoo and Kenneth Burnett and Daniel Crain and Johanna Gardner and Kevin W. Lau and David W. Mallery and Scott Thomas William Morris and Joseph D. Paulauskis and Robert J Penny and Candace Shelton and W. Shelton and Mark M. Sherman and Eric Thompson and Peggy Yena and Melissa T Avedon and Jay Bowen and Julie M. Gastier-Foster and Mark Gerken and Kristen M. Leraas and Tara M. Lichtenberg and N. Carlos Ram{\'i}rez and Tracie Santos and Lisa M. Wise and Erik J. Zmuda and John A. Demchok and Ina Felau and Carolyn M. Hutter and Margi A. Sheth and Heidi Sofia and Roy Tarnuzzer and Zhining Wang and Liming Yang and Jean Claude Zenklusen and Jiashan Zhang and B. Llorente Ayala and Julien Baboud and Sudha Chudamani and Jia Xiang Liu and Laxmi Lolla and Rashi Naresh and T. O. Pihl and Qiang Sun and Yunhu Wan and Ye Wu and Adrian Ally and Miruna Balasundaram and Saianand Balu and Rameen Beroukhim and Tom Bodenheimer and Christian Buhay and Yaron S. N. Butterfield and Rebecca Carlsen and Scott L. Carter and Hsu Chao and Eric Chuah and Amanda Clarke and Kyle R. Covington and Mahmoud Dahdouli and Ninad Dewal and Noreen Dhalla and Harsha Doddapaneni and Jennifer Drummond and Stacey Bolk Gabriel and Richard A. Gibbs and Ranabir Guin and W Dylan Hale and Alicia Hawes and D. Neil Hayes and Robert A. Holt and Alan P. Hoyle and Stuart R. Jefferys and Steven J. M. Jones and Corbin D. Jones and Divya Kalra and Christie L. Kovar and L. Ryan Lewis and Jie Li and Y. P. Ma and Marco A. Marra and Michael Mayo and Shaowu Meng and Matthew Meyerson and Piotr A. Mieczkowski and Richard A. Moore and Donna M. Morton and Lisle E. Mose and Andrew J. Mungall and Donna M. Muzny and Joel S. Parker and Charles M. Perou and Jeffrey Roach and Jacqueline E. Schein and Steven E Schumacher and Yan Shi and Janae V. Simons and Payal Sipahimalani and Tara J. Skelly and Matthew G. Soloway and Carrie L. Sougnez and Angela Tam and Donghui Tan and Nina Thiessen and Umadevi Veluvolu and Min Wang and Matthew Wilkerson and Tina Wong and Junyuan Wu and Liu Xi and Jane H. Zhou and Jason Bedford and Fengju Chen and Yao Fu and Mark Gerstein and David Haussler and Katayoon Kasaian and Phillip Lai and Shiyun Ling and Amie Radenbaugh and David van den Berg and John N. Weinstein and Jingchun Zhu and Monique F. M. A. Albert and Iakovina Alexopoulou and Jeremiah J Andersen and J Todd Auman and John Bartlett and Sheldon Bastacky and Julie Bergsten and Michael L. Blute and Lori Boice and Roni J. Bollag and Jeff Boyd and Erik K Castle and Ying-Bei Chen and John C. Cheville and Erin Curley and Benjamin D Davies and April DeVolk and Rajiv Dhir and Laura Dike and John M Eckman and Jay Engel and Jodi L Harr and Ronald L. Hrebinko and Mei Huang and Lori Huelsenbeck-Dill and Mary Iacocca and Bruce L. Jacobs and Michael Lobis and Jodi Maranchie and Scott D. McMeekin and Jerome K. Myers and Joel T. Nelson and Jeremy Parfitt and Anil Parwani and Nicholas Petrelli and Brenda Rabeno and Somak Roy and Andrew L. Salner and J Garrett Slaton and Melissa Stanton and Robert Thompson and Leigh T Thorne and Kelinda Tucker and Paul M. Weinberger and Cynthia Winemiller and Leigh Anne Zach and Rosemary Zuna},
  journal={The New England journal of medicine},
  volume={374 2},
BACKGROUND Papillary renal-cell carcinoma, which accounts for 15 to 20% of renal-cell carcinomas, is a heterogeneous disease that consists of various types of renal cancer, including tumors with indolent, multifocal presentation and solitary tumors with an aggressive, highly lethal phenotype. Little is known about the genetic basis of sporadic papillary renal-cell carcinoma, and no effective forms of therapy for advanced disease exist. METHODS We performed comprehensive molecular… CONTINUE READING
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