Comprehensive Molecular Characterization of Human Colon and Rectal Cancer

  title={Comprehensive Molecular Characterization of Human Colon and Rectal Cancer},
  author={Mwanja Tenywa Matthew and Natalie Jane Bainbridge and H. A. N. Dinh and Jennifer Drummond and Gerald Fowler and Christie L. Kovar and L. Ryan Lewis and Margaret B. Morgan and Irene F. Newsham and G. Jeffrey and Reid and Jireh Santibanez and Eve Shinbrot and Lisa R. Trevino and Yuan-Qing Wu and Preethi Gunaratne and Albert David and Wheeler and Douglas Voet and Kristian Cibulskis and Andrey Sivachenko and Petar and Stojanov and Aaron McKenna and Eric S. Lander and Daniel C. Koboldt and Jason R. Walker and D. James Dooling and Lucinda L. Fulton and CatrinaC. Fronick and ElaineR. Mardis and Richard and Keith Wilson and Andrew J. Mungall and A Gordon Robertson and Dominik Stoll and Miruna Balasundaram and Yaron S. N. Butterfield and {\'E}ric and Chuah and Robin Coope and Noreen Dhalla and Ranabir Guin and Carrie Hirst and Mart{\'i}n and Hirst and Robert A. Holt and Darlene Lee and A. Richard and Moore and JacquelineE. Schein and JaredR. Slobodan and Yongjun Zhao and Steven J. M. Jones and Hitha Alex and Eva Ramos and Gordon Saksena and S. Schumacher and Barbara Tabak and Scott L. Carter and Robert C. Onofrio and Andrew Crenshaw and Kristin G. Ardlie and Rameen Beroukhim and Wendy Winckler and Gad and Getz and Matthew Meyerson and Lixing Yang and Xiaojia Ren and Psalm Haseley and Jonathan and Seidman and Lynda Chin and Yidi J. Turman and Jan F. Prins and Derek Y. Chiang and D. Neil Hayes and Tom Dennis and Maglinte and Benjamin P. Berman and David J. Van Den Berg and Hui Shen and Stephen B. Baylin and Peter W. Laird and Nils and Gehlenborg and Daniel DiCara and Jun Zhang and Hailei Zhang and Chang-Jiun and P Wu and Spring Yingchun Liu and Sachet A Shukla and Michael Sohn Lawrence and Lihua and Zhou and Pei Yun Lin and Petar Stojanov and Rui Jing and Richard Chan Woo Park and Marc-Danie Nazaire and Jim Robinson and Helga Thorvaldsd{\'o}ttir and Jill P. Mesirov and J F Peter and Park and Lisa Iype and Ryan Bressler and Boris A. Reva and Ronglai Shen and Barry S. Taylor and Timothy and Annette Chan and Stanley R. Hamilton and Ronald C Cason and Joshua M. Stuart and J.... and Zachary Sanborn and Charles J. Vaske and Christopher Szeto and K. Gary and Scott and C B Kenneth Yau and Sam Ng and Ted Goldstein and Kyle Ellrott and Eric A. Collisson and Aaron E. Cozen and W. Graham Richards and Ronny Martin and H Weiser and Joseph E. Willis and Shelley Alonso and Rashmi N. Sanbhadti},
To characterize somatic alterations in colorectal carcinoma, we conducted a genome-scale analysis of 276 samples, analysing exome sequence, DNA copy number, promoter methylation and messenger RNA and microRNA expression. A subset of these samples (97) underwent low-depth-of-coverage whole-genome sequencing. In total, 16% of colorectal carcinomas were found to be hypermutated: three-quarters of these had the expected high microsatellite instability, usually with hypermethylation and MLH1… CONTINUE READING
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