Comprehensive Mass Spectrometric Survey of Streptococcus pyogenes Subcellular Proteomes.

  title={Comprehensive Mass Spectrometric Survey of Streptococcus pyogenes Subcellular Proteomes.},
  author={L. Wilk and L. Happonen and J. Malmstr{\"o}m and H. Herwald},
  journal={Journal of proteome research},
  volume={17 1},
  • L. Wilk, L. Happonen, +1 author H. Herwald
  • Published 2018
  • Biology, Medicine
  • Journal of proteome research
  • Streptococcus pyogenes is a major global health burden causing a wide variety of diseases. Because a vaccine against this bacterium is still lacking, vaccine candidates or antimicrobial therapies are urgently needed. Here we use an invasive and clinically relevant streptococcal M1 serotype to characterize the bacterial proteome in-depth. An elaborate fractionation technique is employed to separate the different cell fractions, followed by shotgun mass-spectrometry analysis, allowing us to… CONTINUE READING
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