Comprehensive Interrogation of Natural TALE DNA Binding Modules and Transcriptional Repressor Domains

@inproceedings{Cong2012ComprehensiveIO,
  title={Comprehensive Interrogation of Natural TALE DNA Binding Modules and Transcriptional Repressor Domains},
  author={Le Chi Cong and Ruhong Zhou and Yu-chi Kuo and Margaret M. Cunniff and Feng Zhang},
  booktitle={Nature communications},
  year={2012}
}
Transcription activator-like effectors are sequence-specific DNA-binding proteins that harbour modular, repetitive DNA-binding domains. Transcription activator-like effectors have enabled the creation of customizable designer transcriptional factors and sequence-specific nucleases for genome engineering. Here we report two improvements of the transcription activator-like effector toolbox for achieving efficient activation and repression of endogenous gene expression in mammalian cells. We show… CONTINUE READING
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