Comprehensive Identification of Krüppel-Like Factor Family Members Contributing to the Self-Renewal of Mouse Embryonic Stem Cells and Cellular Reprogramming

@inproceedings{Jeon2016ComprehensiveIO,
  title={Comprehensive Identification of Kr{\"u}ppel-Like Factor Family Members Contributing to the Self-Renewal of Mouse Embryonic Stem Cells and Cellular Reprogramming},
  author={Hyojung Jeon and Tsuyoshi Waku and Takuya Azami and Le Tran Phuc Khoa and Jun Yanagisawa and Satoru Takahashi and Masatsugu Ema},
  booktitle={PloS one},
  year={2016}
}
Pluripotency is maintained in mouse embryonic stem (ES) cells and is induced from somatic cells by the activation of appropriate transcriptional regulatory networks. Krüppel-like factor gene family members, such as Klf2, Klf4 and Klf5, have important roles in maintaining the undifferentiated state of mouse ES cells as well as in cellular reprogramming, yet it is not known whether other Klf family members exert self-renewal and reprogramming functions when overexpressed. In this study, we… CONTINUE READING
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