Comprehensive Genome-wide Protein-DNA Interactions Detected at Single-Nucleotide Resolution

@article{Rhee2011ComprehensiveGP,
  title={Comprehensive Genome-wide Protein-DNA Interactions Detected at Single-Nucleotide Resolution},
  author={Ho Sung Rhee and B. Franklin Pugh},
  journal={Cell},
  year={2011},
  volume={147},
  pages={1408-1419}
}
Chromatin immunoprecipitation (ChIP-chip and ChIP-seq) assays identify where proteins bind throughout a genome. However, DNA contamination and DNA fragmentation heterogeneity produce false positives (erroneous calls) and imprecision in mapping. Consequently, stringent data filtering produces false negatives (missed calls). Here we describe ChIP-exo, where an exonuclease trims ChIP DNA to a precise distance from the crosslinking site. Bound locations are detectable as peak pairs by deep… CONTINUE READING

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Does CTCF mediate between nuclear organization and gene expression?

  • BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2010
VIEW 3 EXCERPTS